蒲慕明

个人简介

         蒲慕明教授,男,1948年10月31日出生于南京。1970年毕业于台湾清华大学物理系,1974年于美国Johns Hopkins大学获生物物理博士学位,1974-1976年在美国Purdue大学生命科学系从事博士后研究。1976年起先后在美国加州大学Irvine分校、耶鲁大学医学院、哥伦比亚大学、加州大学圣地亚哥分校任教授。目前任加州大学伯克利分校生物科学杰出讲座教授。1999年起任中国科学院神经科学研究所首任及现任所长、神经可塑性研究组组长。主要从事神经元发育与突触可塑性的分子细胞机制研究。共发表了200余篇有关膜生物物理、突触生理、发育神经生物学等方面的研究论文。获得奖项及荣誉称号包括:美国NIH Javitz Neuroscience Investigator Award、台湾中央研究院院士、美国科学院院士、美国AAAS Fellow、美国Ameritec Prize、法国Ecole Normale Geperieure荣誉博士学位、中华人民共和国国际科学技术合作奖等。曾任Journal of Cell Biology、Journal of Neuroscience、Neuron等学术期刊的编委。

 

       作为神经所的所长,显示出其卓越的组织和管理能力,不仅表现在提高研究所的整体学术水平、全方位施行与国际接轨的研究生教育体系,还充分体现在创新文化的建设上。在其领导下神经所自1999年底成立至今在国际著名期刊上发表了许多学术论文,其中包括中国神经科学家全部在国内完成的工作第一次发表在Science、Cell、Nature Neuroscience、Nature Cell Biology、Neuron等刊物上,并得到了国际同行的认可,建立了良好的国际声誉。

主要论著

1.  Poo, M-m. and R.A. Cone. Lateral diffusion of rhodopsin in the photoreceptor membrane.  Nature 247:438-441 (1974).

2.  Poo, M-m.  Rapid lateral diffusion of functional acetylcholine receptors in embryonic muscle membrane.  Nature  295:332-334 (1982).

3.  Young, S.H. and M-m. Poo.  Spontaneous release of transmitter from growth cone of embryonic neuron. Nature  305:634-637 (1983).

4.  Lohof, A., Ip, N. and Poo, M-m.  Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF.  Nature  363: 350-353 (1993).

5.  Song, H-j. Ming, G-l., and Poo M-m.  A cAMP-induced switching of turning direction of nerve growth cones.  Nature  388: 275-279 (1997).

6.  Zhang, L., Tao, H-z., Holt, C., Harris, W., and Poo, M-m.  A critical window in the cooperation and competition among developing retinotectal synapses.  Nature  395: 37-44 (1998). 

7.  Bi, Q. and Poo, M-m.  Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type.  J. Neurosci.  18: 10464-10472 (1998).

8.  Bi, G. and Poo, M-m. Distributed synaptic modification in neural networks induced by patterned stimulation. Nature  401: 792-796 (1999). 

9.  Poo, M-m. Neurotrophins as synaptic modulators.  Nat. Rev. Neurosci.  2: 24-32 (2001).

10.  Bi, G. and Poo, M-m. Synaptic modification by correlated activity: Hebb’s postulate revisited.  Annu. Rev. Neurosci.  24: 139-66 (2001).

 11.  Engart, F., Tao, H., Zhang, L., and M-m. Poo.  Moving stimuli induces direction-sensitive responses of developing tectal neurons.  Nature, 419, 470-474 (2002)  

 12.  Zhou, Q., Tao, H., and M-m. Poo.  Reversal and stabilization of synaptic modifications in a developing visual system.  Science  300, 1953-7 (2003)

13.   Du, J-l. & Poo, M-m.  Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system.  Nature  429: 878-83 (2004) 

14.   Liu, Q-s., Pu, L. &Poo, M-m.  Repeated cocaine exposure facilitates LTP induction in midbrain dopamine neurons.  Nature  437:1027-31(2005)

15.   Dan, Y. & Poo, M-m. Spike timing-dependent plasticity: from synapse to perception. Physiol. Rev. 86:1033-48 (2006). 

16.  Guan, C-b, Xu, H-t., Yuan, X-b. & Poo, M-m.  Long-range Ca2 signaling mediates reversal of neuronal migration induced by Slit-2.  Cell, l29: 385-395 (2007)

17.   Shelly, M., Cancedda, L., Sumbre, G. & Poo, M-m.  LKB1/STRAD promotes axon initiation during neuronal polarization.  Cell, 129: 565-77 (2007)

18.   Sumbre, G., Muto, A., Baier H., Poo M-m. Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval.. Nature 456:102-6 (2008)

19.   Song A.H., Wang D., Chen G., Li Y., Luo J., Duan S, & Poo M-m. A selective filter for cytoplasmic transport at the axon initial segment, Cell , 136: 1148-60 (2009)

20.   Shelly, M., Lim, B.K., Cancedda L., Heilshorn, S.C., Gao H., Poo M-m. Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation. Science. 327: 547-52 (2010).  

 

Writings on Chinese Science

          1.  Poo, M-m. Cultural reflections.  Nature  428 : 204-5 (2004)

2.  Poo, M-m. Big Science, Small Science, Supplement to Nature (in Chinese) (2006)

3.  Poo M-m., Sander, L., Fivaz, M., Hayashi, Y. Asian promise: the state and future of collaborations in neuroscience. Nature Review Neuroscience. 11: 881-4 (2008).

4.  Poo, M-m.  Neuroscience in China 2000-2009: Introduction.  Science China, 53:301-303 (2010)

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